Susan G Hilsenbeck Selected Research

Neoplasm Metastasis (Metastasis)

4/2024	LOAd703, an oncolytic virus-based immunostimulatory gene therapy, combined with chemotherapy for unresectable or metastatic pancreatic cancer (LOKON001): results from arm 1 of a non-randomised, single-centre, phase 1/2 study.
1/2023	Multiomics in primary and metastatic breast tumors from the AURORA US network finds microenvironment and epigenetic drivers of metastasis.
1/2022	Targeting the Pro-survival Protein BCL-2 to Prevent Breast Cancer.
1/2021	Hormonal modulation of ESR1 mutant metastasis.
12/2017	EMT cells increase breast cancer metastasis via paracrine GLI activation in neighbouring tumour cells.
11/2017	Tenascin-C and Integrin α9 Mediate Interactions of Prostate Cancer with the Bone Microenvironment.
1/2015	A phase II trial of capecitabine concomitantly with whole-brain radiotherapy followed by capecitabine and sunitinib for brain metastases from breast cancer.
11/2014	The oncogenic STP axis promotes triple-negative breast cancer via degradation of the REST tumor suppressor.
10/2013	Metastasis tumor-associated protein 2 enhances metastatic behavior and is associated with poor outcomes in estrogen receptor-negative breast cancer.
8/2011	A moderate elevation of circulating levels of IGF-I does not alter ErbB2 induced mammary tumorigenesis.

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Susan G Hilsenbeck Research Topics

Disease

101	Breast Neoplasms (Breast Cancer) 01/2024 - 05/2002
98	Neoplasms (Cancer) 01/2024 - 05/2002
16	Neoplasm Metastasis (Metastasis) 04/2024 - 05/2004
14	Triple Negative Breast Neoplasms 03/2024 - 03/2011
11	Carcinogenesis 01/2015 - 05/2002
3	Adenocarcinoma 04/2024 - 02/2012
3	Pathologic Complete Response 01/2023 - 01/2011
3	Noninfiltrating Intraductal Carcinoma (DCIS) 01/2022 - 10/2007
3	Prostatic Neoplasms (Prostate Cancer) 11/2017 - 05/2010
3	Hyperplasia 10/2007 - 01/2006
2	Leukemia 10/2022 - 01/2019
2	Arthralgia (Joint Pain) 09/2019 - 01/2018
2	Carcinoma (Carcinomatosis) 01/2019 - 06/2013
2	Tics (Tic) 10/2014 - 02/2012
2	Shock 02/2009 - 02/2008
2	Erythema 09/2006 - 05/2002
1	Pancreatic Neoplasms (Pancreatic Cancer) 04/2024
1	Fever (Fevers) 04/2024
1	Fatigue 04/2024
1	Chills 04/2024

Drug/Important Bio-Agent (IBA)

42	Estrogen ReceptorsIBA 01/2024 - 09/2002
25	Proteins (Proteins, Gene)FDA Link 10/2023 - 05/2002
21	Tamoxifen FDA LinkGeneric 01/2021 - 03/2003
17	Lapatinib (GW572016)FDA Link 01/2023 - 05/2008
16	Trastuzumab (Herceptin)FDA Link 01/2023 - 12/2003
15	Progesterone Receptors (Progesterone Receptor)IBA 01/2022 - 03/2003
12	Phosphotransferases (Kinase)IBA 01/2023 - 10/2002
10	Hormones (Hormone)IBA 01/2024 - 04/2004
9	Estrogens (Estrogen)FDA Link 01/2021 - 10/2002
9	ErbB Receptors (EGF Receptor)IBA 11/2015 - 02/2006
9	Docetaxel (Taxotere)FDA Link 01/2012 - 08/2003
8	Phosphoric Monoester Hydrolases (Phosphatases)IBA 03/2024 - 01/2011
8	Phenobarbital (Luminal)FDA Link 01/2023 - 09/2008
8	RNA (Ribonucleic Acid)IBA 01/2023 - 01/2006
8	Estrogen Receptor alphaIBA 01/2021 - 09/2002
7	Messenger RNA (mRNA)IBA 01/2024 - 01/2006
7	Biomarkers (Surrogate Marker)IBA 01/2023 - 12/2005
7	Estrogen Receptor Modulators (Antiestrogen)IBA 01/2021 - 04/2005
5	human ERBB2 proteinIBA 01/2024 - 02/2006
5	Transcription Factors (Transcription Factor)IBA 01/2020 - 10/2002
5	Transcription Factor AP-1 (Transcription Factor AP 1)IBA 01/2016 - 10/2002
5	Bexarotene (LGD1069)FDA Link 02/2009 - 05/2002
4	Fulvestrant (Faslodex)FDA Link 01/2023 - 07/2014
4	DNA (Deoxyribonucleic Acid)IBA 01/2023 - 06/2007
4	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2023 - 09/2014
4	Co-Repressor ProteinsIBA 01/2020 - 01/2006
4	IntegrinsIBA 01/2020 - 07/2011
4	Small Interfering RNA (siRNA)IBA 07/2014 - 12/2009
4	Insulin-Like Growth Factor I (IGF-1)IBA 02/2012 - 09/2008
4	Protein Isoforms (Isoforms)IBA 06/2011 - 04/2004
4	Tyrosine Kinase InhibitorsIBA 04/2011 - 09/2008
3	Formaldehyde (Formol)FDA Link 01/2022 - 10/2006
3	ParaffinIBA 01/2022 - 10/2006
3	Aromatase InhibitorsIBA 01/2021 - 01/2018
3	Estradiol (Delestrogen)FDA LinkGeneric 01/2021 - 02/2012
3	Androgen Receptors (Androgen Receptor)IBA 01/2021 - 05/2010
3	Letrozole (Femara)FDA LinkGeneric 01/2020 - 08/2009
3	CarcinogensIBA 10/2019 - 05/2002
3	Interleukin-8 (Interleukin 8)IBA 10/2016 - 06/2013
3	ClaudinsIBA 10/2014 - 08/2009
3	RetinoidsIBA 04/2005 - 05/2002
2	InterferonsIBA 10/2023 - 09/2023
2	RNA Helicases (RNA Helicase)IBA 10/2023 - 09/2023
2	Immune Checkpoint InhibitorsIBA 10/2023 - 09/2023
2	Carboplatin (JM8)FDA LinkGeneric 10/2023 - 09/2023
2	Neurofibromin 1 (Neurofibromin)IBA 01/2023 - 01/2020
2	neratinibIBA 05/2021 - 09/2017
2	Leucine (L-Leucine)FDA Link 01/2021 - 01/2020
2	ChromatinIBA 01/2020 - 10/2016
2	CytokinesIBA 01/2018 - 06/2013
2	Tyrosine (L-Tyrosine)FDA Link 01/2018 - 03/2011
2	TenascinIBA 11/2017 - 11/2015
2	Indicators and Reagents (Reagents)IBA 03/2016 - 01/2016
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2016 - 10/2002
2	LigandsIBA 05/2015 - 12/2006
2	TensinsIBA 09/2014 - 01/2011
2	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 09/2014 - 01/2010
2	Interleukin-6 (Interleukin 6)IBA 06/2013 - 02/2008
2	Insulin-Like PeptidesIBA 02/2012 - 04/2011
2	rho GTP-Binding Proteins (rho GTP-Binding Protein)IBA 04/2011 - 01/2010
2	rho GTPase-activating proteinIBA 01/2010 - 01/2009
2	Growth Factor ReceptorsIBA 01/2010 - 02/2006
2	Gefitinib (Iressa)FDA Link 02/2009 - 09/2008
2	Doxycycline (Periostat)FDA LinkGeneric 06/2008 - 10/2002
2	Retinoid X Receptors (Retinoid X Receptor)IBA 04/2005 - 11/2002
1	Transaminases (Aminotransferases)IBA 04/2024
1	Alkaline PhosphataseIBA 04/2024
1	Alanine Transaminase (SGPT)IBA 04/2024
1	Gemcitabine FDA Link 04/2024
1	EnzymesIBA 04/2024
1	130-nm albumin-bound paclitaxelIBA 04/2024

Therapy/Procedure

57	Therapeutics 01/2024 - 03/2003
19	Drug Therapy (Chemotherapy) 04/2024 - 08/2003
4	Neoadjuvant Therapy 01/2023 - 02/2005
4	Aftercare (After-Treatment) 11/2015 - 02/2005
3	Radiotherapy 05/2018 - 10/2010
3	Transplantation 10/2014 - 01/2009
2	Chemoprevention 12/2013 - 06/2013
2	Resuscitation 02/2009 - 02/2008
1	Injections 04/2024